Dupilumab is a monoclonal antibody that targets interleukin-4 (IL-4) and IL-13, two cytokines involved in the development of atopic dermatitis. In clinical trials, dupilumab was found to be efficacious in treating moderate to severe atopic dermatitis. The most common side effect associated with dupilumab is injection site reactions. Dyshidrotic eczema is a type of eczema that results in blisters on the hands and feet. While not commonly reported, dyshidrotic eczema has been seen as a potential side effect of dupilumab use. ( Read the introduction letter of the pharmaceutical company. Link sanofi)
If you have eczema, your skin is probably very dry, itchy, and red. You may also have blisters that ooze clear fluid. These can be uncomfortable or even painful. Dyshidrotic eczema is a type of eczema that affects the hands and feet. It’s also called pompholyx or vesicular palmoplantar dermatitis. This condition can make everyday activities difficult to do because of the pain and itching. But there are treatments that can help relieve your symptoms and heal your skin.
What is dyshidrotic eczema?
Dyshidrotic eczema is a type of eczema that results in small, fluid-filled blisters on the palms of your hands and the soles of your feet. The word “dyshidrosis” comes from the Greek words for “difficulty” (dus-) and “sweat” (-hydros). So, dyshidrosis means difficult sweating. Dyshidrotic eczema is also called pompholyx or vesicular palmoplantar dermatitis. It can affect anyone at any age, but it’s more common in women and people between 20 and 40 years old. People with this condition may have sudden onset or flares followed by periods of remission when symptoms go away completely or almost completely.
What causes dyshidrotic eczema ?
The exact cause of dyshidrotic eczema isn’t known. However, it’s believed to be related to an overactive immune system response to something that doesn’t bother most people. This triggers inflammation deep in the skin, which eventually leads to the formation of tiny blisters. Some possible triggers include allergies, stress, metal ions present in some soaps or cosmetics, and contact with certain plants such as poison ivy. Genetics may also play a role since this condition often runs in families.
What are the symptoms of dyshidrotic eczema?
The most common symptom of dyshidrotic eczema is small, fluid-filled blisters that form on your palms and soles. These can be itchy or even painful. The blisters usually clear up within a few weeks without treatment, but they may come back (recur). Other possible symptoms include dry, cracked skin redness itching burning sensation swelling bumps .
How is dyshidrotic eczema diagnosed?
Your doctor will likely be able to diagnose dyshidrotic eczema based on a physical exam and your medical history. He or she may also use a lighted microscope to look at a sample of the affected skin (biopsy). This can help rule out other conditions with similar symptoms, such as allergic contact dermatitis or psoriasis.
What are the treatments for dyshidrotic eczema?
There is no cure for dyshidrotic eczema, but there are treatments that can help relieve your symptoms and heal your skin. These include Corticosteroid creams or ointments. These can be applied to the affected areas of the skin to reduce inflammation. Your doctor may also prescribe a stronger corticosteroid cream or ointment if over-the-counter products don’t work. Oral antihistamines . These can help relieve itching caused by blisters. Antihistamines may make you drowsy, so they’re usually only used at night before bedtime. Immune system suppressors. In severe cases of dyshidrotic eczema, your doctor may prescribe medications that suppress your immune system response (immunosuppressants). This helps prevent new flares from occurring while you’re being treated with other therapies. Phototherapy, which uses ultraviolet light waves to improve symptoms, is sometimes used in addition to topical treatment options listed above.